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Specifically, those starting GLP-1RA had a significantly higher risk of thyroid cancer within the first year of treatment (HR 1.85), compared to those taking other diabetes medications, such as sodium-glucose cotransporter 2 inhibitors (SGLT2i), dipeptidyl peptidase-4 inhibitors (DPP4i), or sulfonylureas

Compared to the NCD group, the HFD group exhibited 312 significantly altered metabolites (172 up-regulated and 140 down-regulated) (Fig

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